Quake, pfff. Working in Windows without mouse can be a huge pain and therefore a challenge.

For example Firefox with keyboard only is masochistic experience of clicking tab key to get to a link/textarea/button.
Speaking of challenge, I once played Tomb Raider trying not to kill anyone. I almost finished 2nd level. Does anyone played Quake or some other shooter this way

There will be problems doing so, because sometimes a path is locked until You kill all monsters ... I also played Thief The Dark Project this way.
Think, touch, movetype, solid, traceline ...